It’s possible for liquid products exposed to low temperature to freeze. For example, during cold months in high latitudes, water-based products can freeze during transit. Some solvents have high freezing temperatures so they can freeze above water’s freezing temperature. If your product froze and the bottle didn’t crack it’s OK, it just needs to be warmed to room temperature. Some products can precipitate out of solution if exposed to low temperature. If that happens you can run the bottle under warm water and shake vigorously before administration to re-suspend and re-solve.